張洪波
E-mail: hbzhang@ecust.edu.cn
職位: 博士生導(dǎo)師
職稱: 教授
個(gè)人簡介:
張洪波 教授 博士生導(dǎo)師 畢業(yè)于華中科技大學(xué)，2004年獲得英國諾丁漢特倫特大學(xué) 博士學(xué)位。2004-2006分別在英國女王大學(xué)和倫敦大學(xué)作博士后研究。2006.10月就職于華東理工大學(xué)致力微流體技術(shù)在生物醫(yī)藥中的應(yīng)用研究。先后受到國家自然科學(xué)基金、上海市對外合作基金、上海市飛利浦合作基金、上海市創(chuàng)新行動(dòng)計(jì)劃等項(xiàng)目資助，與英國女王大學(xué)、倫敦大學(xué)及國內(nèi)近10家醫(yī)療機(jī)構(gòu)開展了廣泛的合作。中國生物材料協(xié)會(huì)先進(jìn)制造分會(huì)委員；3D打印專業(yè)委員會(huì)委員；在3D生物打印技術(shù)及器官芯片技術(shù)方面發(fā)表50余篇SCI論文，十余項(xiàng)專利授權(quán)。
聯(lián)系方法:
梅隴路130號華東理工大學(xué)401信箱，上海 200237
Tel: 0086-21-64253538
Email: hbzhang@ecust.edu.cn
研究方向
(1）生物 3D 打印技術(shù)
生物 3D 打印構(gòu)建骨、皮膚、氣管組織及腫瘤模型；
開發(fā)熔融及電紡、擠出式及光固化生物3D打印技術(shù)
(2）微流控與器官芯片技術(shù)
微納米顆粒、腫瘤細(xì)胞分離及載藥緩釋微球、微泡造影劑制備
模擬體內(nèi)微環(huán)境，構(gòu)建皮膚、腎器官芯片用于藥物篩選；
(3）個(gè)性化可穿戴智能型外骨骼護(hù)具及智能傳感開發(fā)
構(gòu)建柔性欠驅(qū)動(dòng)假肢、肩、肘、手可穿戴式外骨骼護(hù)具；
姿態(tài)捕捉及生理信號結(jié)合用于步態(tài)、能耗分析及康復(fù)效果評估
承擔(dān)科研項(xiàng)目
承擔(dān)項(xiàng)目：
（1）上海市科委創(chuàng)新行動(dòng)計(jì)劃 新型抗菌水凝膠敷料的研發(fā)和臨床前評價(jià)，2019.4-2022.3
?。?）上海市科委“聯(lián)盟計(jì)劃” 3D打印活體皮膚組織塊用于藥物篩選研發(fā)，2016.7-2018.1
?。?）國家自然科學(xué)青年基金，微氣泡造影劑對癌癥的基因治療的基礎(chǔ)研究，2008-2010；
?。?）上海市科委非政府合作基金，微流體聚焦法制備治療型微氣泡造影劑的研究，2010-2012；
?。?）上海市飛利浦合作基金，治療型微氣泡造影劑新型制備方法的可行性研究，2007-2009；
企業(yè)合作項(xiàng)目：
獲得多項(xiàng)企業(yè)、醫(yī)療機(jī)構(gòu)聯(lián)合課題資助
獲獎(jiǎng)成果
(1) 2014年獲得華東理工大學(xué)育英獎(jiǎng)一等獎(jiǎng)；
(2) 2013年獲得上海市教學(xué)成果一等獎(jiǎng)：機(jī)械與化工復(fù)合型人才多維度工程能力培養(yǎng)的研究與實(shí)踐；
(3) 2013年上?；^(qū)理工教學(xué)二等獎(jiǎng)
代表性著作
(1) Jianxu Wei, Xiaomeng Zhang, Zhuo Zhang, Xinxin Ding, Yuan Li, Yi Zhang, Xue Jiang, Hongbo Zhang*, Hongchang Lai* 1, Junyu Shi* . On-off Switch of Bioenergetic Channels Regulated by Curcumin-loaded 3D Composite Scaffold to Steer Bone Regeneration. Chemical Engineering Journal, 2023, 452(1):139165.
(2) Pan Aixing, Ding Hongtao, Wang Junjie, Zhang Zhuo, Zhang Hongbo, Liu Yuzeng and Hai Yong. The application of finite element analysis to determine the optimal UIV of growing rod treatment in early-onset scoliosis. Front. Bioeng. Biotechnol. 2022,10:978554. doi: 10.3389/fbioe.2022.978554
(3) Ruixue Yin, Jizhong Xin , Dasheng Yang , Yang Gao , Hongbo Zhang *, Zhiqin Qian and Wenjun Zhang ，High-Linearity Hydrogel-Based Capacitive Sensor Based on Con A–Sugar Affinity and Low-Melting-Point Metal，Polymers 2022, 14, 4302.
(4) Wenxuan Sun, Zijia Liu , Jian Xu , Ya Cheng , Ruixue Yin , Lei Ma , Honglin Li , Xuhong Qian , Hongbo Zhang* , 3D skin models along with skin-on-a-chip systems: A critical review, Chinese Chemical Letters, 2022，107819. doi:https://doi.org/10.1016/j.cclet.2022.107819
(5) Di Yin, Hongbo Zhang, Chun Yang, Wenjun Zhang, and Shihmo Yang. A More Biomimetic Cell Migration Assay with High Reliability and Its Applications, Pharmaceuticals 2022, 15(6), 695; https://doi.org/10.3390/ph15060695
(6) Yilin Yan, Katharine Smith*, Alejandro Macario-Rojas and Hongbo Zhang *, Simulation of the Landing Buffer of a Three-Legged Jumping Robot. Machines 2022,10,299. https:// doi.org/10.3390/machines10050299
(7) ShihMoYang, QiangLin, HongboZhang,RuixueYin, Wenjun Zhang, Minchao Zhang,Yubao Cui. Dielectrophoresis assisted high-throughput detection system for multiplexed immunoassays. Biosensors and Bioelectronics, 180, 15 May 2021, 113148. https://doi.org/10.1016/j.bios.2021.113148
(8) Yingjie Cai, Dasheng Yang, Ruixue Yin*, Yang Gao*, Hongbo Zhang* and Wenjun Zhang, An enzyme-free capacitive glucose sensor based on dual-network glucose-responsive hydrogel and coplanar electrode, The Analyst, 2021,146(1), 213-221.
(9) Zhitao Liu, Hongbo Zhang* and Huanxin Lai*, Fluid flow effects on the degradation kinetics of bioresorbable polymers, Computer Methods in Biomechanics and Biomedical Engineering, 2021, DOI: 10.1080/10255842.2020.1867115.
(10) Tiandi Wang, Jianchao Zheng, Tianzhou Hu, Hongbo Zhang, Kun Fu, Ruixue Yin and Wenjun Zhang. Three-Dimensional Printing of Calcium Carbonate/Hydroxyapatite Scaffolds at Low Temperature for Bone Tissue Engineering. 3D printing and additive manufacturing, 2021, 8(1)，1-13. DOI: 10.1089/3dp.2020.0140.
(11) Jinling Zhu,Minqi Wang, Hongbo Zhang*,Shengbing Yang*, Ki-Young Song, Ruixue Yin and Wenjun Zhang. Effects of Hydrophilicity, Adhesion Work, and Fluid Flow on Biofilm Formation of PDMS in Microfluidic Systems. ACS Applied Bio Materials, 2020, 3. 10.1021/acsabm.0c00660.
(12) P.W. Xu, F.L. Jiang, H.B. Zhang*, R.X. Yin, L. Cen and W.J. Zhang*. Calcium Carbonate / Gelatin Methacrylate Microspheres for 3D Cell Culture in Bone Tissue Engineering Part C, 2020, 26 (8), 418-432. (IF:2.608)
(13)S.Y. Gai, J.J. Xu, H.B. Zhang*, R.X. Yin and W.J. Zhang*. Effects of Nanofillers on the Hydrolytic Degradation of Polyesters. Tissue engineering part B, March, 5th, 2020, published online. （IF:6.512)
(14) L. Lei, H.B. Zhang*, D. Bergstrom, T. Anthony, K.Y.Song, W.J. Zhang*. Experimental and simulation study of flow patterns in the combined flow focusing and T-junction device. Journal of Micromechanics and Microengineering, 2020, 30, 055001. (IF: 2.15)
(15) H.P. Si, T.L. Xing, Y.L. Ding, H.B. Zhang*, R.X. Yin and W.J. Zhang. 3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels. Polymers 2019, 11(10), 1584.（IF:3.363）
(16) Y.H. Jia, H.B. Zhang*, S.B. Yang*, Z.H. Xi, T.T. Tang, R.X. Yin, W.J. Zhang. Electrospun PLGA membrane incorporated with Andrographolide-loaded Mesoporous Silica Nanoparticles for sustained antibacterial wound dressing. Nanomedicine, 2018, 13(22):2881-2899. (IF:5.005
(17) C.H. Ma, H.B. Zhang*, S. M. Yang, R. X. Yin, X. J. Yao, and W. J. Zhang. Comparison of the degradation behavior of PLGA scaffolds in micro-channel, shaking, and static conditions. Biomicrofluidics, 2018, 12, 034106.（IF:2.571）
(18)Y. Shi, T.L. Xing, H.B. Zhang*, R.X. Yin, Sh. M. Yang, J. Wei and W.J. Zhang. Tyrosinase doped bioink for 3D bioprinting of living skin constructs. Biomedical materials, 2018, 13, 035008.（IF:2.897）
(19) Y. Yang, L.Y. Chu, S.B. Yang, H.B. Zhang, L. Qin, O. Guillaume, D. Eglin, R. G. Richards, T.T. Tang. Dual-functional 3D-printed composite scaffold for inhibiting bacterial infection and promoting bone regeneration in infected bone defect models. Acta Biomaterialia, 2018, 79:265-275 46:112-128.（IF:6.319）
(20) S.B. Yang, X.G. Han, Y.H. Jia, H.B. Zhang* and T.T. Tang*. Hydroxypropyltrimethyl Ammonium Chloride Chitosan Functionalized-PLGA Electrospun Fibrous Membranes as Antibacterial Wound Dressing: In Vitro and In Vivo Evaluation. Polymers 2017, 9(12), 697.（IF:3.363）
(21) L. Lei, D. Bergstrom, B. Zhang, H.B. Zhang*, R. Yin, K.Y. Song and W.J. Zhang*. Micro/Nanospheres Generation by Fluid-Fluid Interaction Technology: A Literature Review. Recent Patents on Nanotechnology, 2017, 11, 15-33.（IF: 1.475）
(22) R. Yin, N. Zhang, K. Wang, H. Long, T.L. Xing, J. Nie, H.B. Zhang and W.J. Zhang. Material design and photo-regulated hydrolytic degradation behavior of tissue engineering scaffolds fabricated via 3D fiber deposition. Journal of Materials Chemistry B, 2017, 5, 329-340.（IF:4.543）
(23) Z.M. Du, N.F. Li, Y.J. Hua, Y. Shi, C.Y. Bao, H.B. Zhang, Y. Yang, Q.N. Lin, L.Y. Zhu. Physiological pH-dependent gelation for 3D printing based on the phase separation of gelatin and oxidized dextran. Chemical Communication, 2017, 53(97):13023-13026. (IF:6.29)
(24) H.B. Zhang*, T.L.Xing, Y. Shi, R.X.Yin, S.M.Yang and W.J. Zhang. 3D bioprinting is not only about cell-laden structures. Chinese Journal of Traumatology, 2016, 19:187-192. (MEDLINE)
(25) S. Duan, K. Yang, Z.H. Wang, M.T. Chen, L. Zhang*, H.B. Zhang* and C.Z. Li, Fabrication of Highly Stretchable Conductors Based on 3D Printed Porous Poly(dimethylsiloxane) and Conductive Carbon Nanotubes/Graphene Network, ACS Applied Materials & Interface, 2016, 27;8(3):2187-92.（IF:8.097）
(26) Y. Yang, S.B. Yang, Y. Wang, Z.F. Yu, H.Y. Ao, H.B. Zhang, L. Qin, O. Guillaume, D. Eglin, R.G. Richards and T.T. Tang. Anti-infective efficacy, cytocompatibility and biocompatibility of a 3D-printed osteoconductive composite scaffold functionalized with quaternized chitosan, Acta Biomaterialia, 2016, 46:112-128.（IF:6.319）
(27) H.B. Zhang, L. Zhou, and W.J. Zhang*. Control of Scaffold Degradation in Tissue Engineering: A Review. Tissue Engineering Part B, 2014, 10(5), 492-502.（IF:6.512）
(28) J. Xu, Y. Xie, H.B. Zhang*, Z. Ye*, W.J. Zhang. Fabrication of PLGA/MWNTs composite electrospun fibrous scaffolds for improved myogenic differentiation of C2C12 cells. Colloids and Surfaces B: Biointerfaces, 2014, 123, 907-915.（IF:3.977）
(29) B. Zhang, M.A.J. Moser, E.M. Zhang, Y. Luo, H.B. Zhang, W.J. Zhang. Study of the relationship between the target tissue necrosis volume and the target tissue size in liver tumours using two-compartment finite element RFA modelling. International Journal of Hyperthermia, 2014; 30(8): 593-602. （IF:3.262）
(30)H.B. Zhang, Y.Y. Yan, Y.Q. Zu. Numerical modelling of EHD effects on heat transfer and bubble shapes of nucleate boiling. Applied Mathematical Modeling, 2010, 34: 626-638.（IF:2.68）
(31) J. Wei, J.F. Jia, F. Wu, S.C. Wei, H. Zhou, H.B. Zhang. Hierarchically microporous /macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration. Biomaterials, 2010, 31, 1260–1269. (IF:8.4604)
(32) Z. Ahmad, H.B. Zhang, U. Farook, M. Edirisinghe, E. Stride, P. Colombo. Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow.Journal of the Royal Society Interface, 2008, 5(27), 1255-1261.（IF: 3.574）
(33) U. Farook, H.B. Zhang, M. Edirisinghe, E. Stride, N. Saffari. Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Medical Engineering Physics. 2007, 29(7): 749-754. (IF:1.819）
(34) H.B. Zhang and M.J. Edirisinghe. Electrospinning of Zirconia fibers from a suspension, Journal of American Ceramic Society. 2006, 89 (6): p1870-1875.（IF:2.956）
(35) H.B. Zhang, S.N. Jayasinghe and M.J. Edirisinghe. Electrically forced microthreading of highly viscous dielectric liquids, Journal of Electrostatics, 2006, 64, p355-360.（IF:1.135）
(36) H.B. Zhang, M.J. Edirisinghe and S.N. Jayasinghe. Flow behaviour of dielectric liquids in an electric field, Journal of Fluid Mechanics, 2006, 558: p103-111.（IF:2.821）
(37) Q.Z. Chen, A.R. Boccaccini, H.B. Zhang, D.Z. Wang and M.J. Edirisinghe. Improved mechanical reliability of bone tissue engineering Scaffolds (zirconia) by electrospraying, Journal of American Ceramic Society, 2006, 89 (5): 1534-1539.（IF:2.841）